• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention is a method for estimating a heart rate by detecting radiation backscattered or transmitted by a body area. Said part is illuminated, simultaneously or successively, by light radiation extending over a first spectral band and a second spectral band. A photodetector detects radiation emitted by said body zone under the effect of its illumination, in each of the spectral bands. A first detection function and a second detection function are respectively formed from the radiation detected in each spectral band. The method allows determination of the heart rate by determining characteristic moments identified simultaneously from the first detection function and the second detection function.
    公开号:FR3048173A1
    申请号:FR1651656
    申请日:2016-02-29
    公开日:2017-09-01
    发明作者:Sylvain Stanchina；Anne Koenig
    申请人:Commissariat a lEnergie Atomique CEA；Commissariat a lEnergie Atomique et aux Energies Alternatives CEA；
    IPC主号:
    专利说明:

    Method for estimating a heart rate and associated device
    Description
    TECHNICAL AREA
    The technical field of the invention is the optical measurement of a heart rate of an individual or an animal.
    PRIOR ART
    Optical measurements are frequently used to determine physiological parameters of a living being, in particular related to blood. Devices, known as pulse oximeters, are commonly used to determine oxygen saturation of hemoglobin in the blood. These measurements are based on the absorption of light by hemoglobin, the latter varying between oxyhemoglobin and deoxyhemoglobin. Commercial devices are widely used, based on a measurement of light transmitted by a sufficiently thin body, in an infrared spectral band and a red spectral band. The examined organ may be in particular the end of a finger or the lobe of an ear. Measurements of the transmitted light, in each of the spectral bands, make it possible to estimate concentrations of oxyhemoglobin and deoxyhemoglobin in the blood, from which the oxygen saturation of the blood is estimated. These measurements also make it possible to detect a pulsatile flow of blood and to deduce a heart rate. Most commercial oximeters also allow an estimate of heart rate from measurements made in either spectral band.
    The European patent EP2355693 describes for example a device comprising a first light source emitting in a red wavelength and a second light source emitting in an infra-red wavelength. A photodetector is capable of detecting a light beam emanating from a finger illuminated by one of said light sources. The infra-red light source is used in particular to detect the presence of the finger against the device, after which the red light source is activated, so as to allow a determination of parameters such as heart rate or pulse oximetry.
    US Patent US9042971 discloses a nomadic actimetry device for optically determining a heart rate by detecting a light radiation backscattered by a finger under the effect of illumination. This device makes it possible to perform measurements in a backscattering configuration, also referred to as the reflectance configuration, the light sources being disposed adjacent to the photodetector.
    The inventors have found that such devices can generate errors in measuring the heart rate, especially when worn by a person in motion. The invention proposes to solve this problem, by making it possible to obtain more reliable measurements of the heart rate.
    SUMMARY OF THE INVENTION
    A first object of the invention is a method for estimating a heart rate of a living being comprising the following steps: a) illumination of a body area of said living being by an incident light beam according to a first spectral band; b) detecting transmitted or backscattered light radiation in said spectral band by said body area under the effect of said illumination; c) determining a first detection function, representing a temporal evolution of an intensity of the light radiation thus detected; d) identifying characteristic instants from said first detection function, and calculating a frequency of occurrence of said characteristic moments; e) estimating a heart rate from said frequency of occurrence; the method being characterized in that: steps a) to b) are also implemented in a second spectral band, preferably different from the first spectral band, so that step c) comprises a determination of a second detection function representing a time evolution of an intensity of the light radiation detected in the second spectral band; step d) comprises an identification of characteristic instants from the second detection function and a selection of characteristic instants identified from each detection function, and appearing in time coincidence, the frequency of occurrence being calculated from the characteristic moments thus selected. Step d) may comprise a calculation of a first function derived from the first detection function, and a second function derived from the second detection function, as well as the identification of characteristic instants at from each of said derived functions. Each derived function can be obtained by a difference between the value of a detection function at two different times.
    By temporal coincidence, we mean simultaneously, that is to say in the same time window. This time window can be predetermined or adjustable.
    By light beam or light radiation is meant a flow of photons whose spectral band is in the visible range, or near infra-red, or near UV, for example between 200 nm and 1000 nm.
    The heart rate may be equal to the frequency of occurrence.
    The method may comprise one of the following characteristics, taken separately or in combination: the first spectral band has wavelengths between 600 and 700 nm; the second spectral band has wavelengths between 750 nm and 1 pm; the first spectral band extends between 600 nm and 700 nm, and / or the second spectral band extends between 750 nm and 1 μm, and preferably between 810 nm and 1000 nm; the first spectral band extends, mainly or in whole, below 805 nm, while the second spectral band extends, predominantly or in whole, above 805 nm.
    The detected radiation may be backscattered radiation, in which case the light source and the photodetector are disposed adjacent to each other. The detected radiation may also be transmitted radiation, in which case the body region extends between the light source and the photodetector.
    Preferably, the first spectral band and the second spectral band do not overlap, or negligibly.
    Another subject of the invention is a device for estimating a heart rate of a living being, comprising: a light source capable of emitting an incident light beam propagating towards a body zone of said living being, according to a first spectral band and according to a second spectral band; a photodetector able to detect, in each spectral band, a radiation backscattered or transmitted by said body zone, under the effect of its illumination by said incident light beam; a processor, configured to implement steps c) to e) of the method described in this application.
    The photodetector may be able to detect radiation backscattered by said body area under the effect of its illumination. Alternatively, the photodetector is able to detect radiation transmitted by the illuminated body area.
    The light source may comprise: a first elementary light source, able to emit a first incident light beam according to the first spectral band; a second source of elementary light capable of emitting a second incident light beam according to the second spectral band. Other advantages and features will emerge more clearly from the following description of particular embodiments of the invention, given by way of non-limiting examples, and represented in the appended figures, listed below.
    FIGURES
    Figures IA and IB respectively represent a first and a second example of a device adapted to implement the invention.
    FIG. 2A shows a detection function obtained following the detection of a backscattered radiation of a body area under the effect of illumination.
    FIG. 2B represents a so-called derived function, obtained from a detection function as represented in FIG. 2A.
    Figure 3A shows a detail of a detection function, and its derived function, as a function of time. It illustrates the occurrence of an untimely forehead.
    Figure 3B shows time-based estimates of an individual's heart rate as a function of a detected signal in response to illumination in a spectral band respectively centered at 660 nm and 940 nm. These estimates are made according to a method of the prior art and were undertaken by illuminating the thumb of an individual in a backscatter pattern.
    FIG. 4A represents the main steps of a method according to the invention. Figure 4B illustrates each illumination sequence of the method.
    FIGS. 5A and 5B respectively show the detection of characteristic instants from a first detection function and a second detection function.
    Figure 6A is identical to Figure 3B. Fig. 6B shows an evaluation of the heart rate of an individual, embodying the invention, as a function of the signals detected to establish Fig. 6A.
    Figure 6C is an evaluation of the heart rate of an individual, performed according to a method of the prior art, by illuminating the wrist of an individual. Figure 6D is an evaluation of heart rate, embodying the invention, based on the signals detected to establish Figure 6C.
    Figs. 6A to 6D are realized by implementing the method in a backscattering configuration.
    DESCRIPTION OF PARTICULAR EMBODIMENTS
    FIG. 1A represents an example of a device 1 allowing the implementation of the invention. A light source 10 emits an incident light beam 12 propagating to a sample 20 along an axis of propagation Z. The term sample designates a body zone of a living being whose heart rate is to be acquired. The photons composing the incident light beam 12 penetrate into the sample and part of them is backscattered in a direction parallel to the axis of propagation, in a direction opposite to the latter. These backscattered photons constitute backscattered radiation 14. The backscattered radiation 14 can be detected by a photodetector 30, placed facing the surface 21 of the sample. The photodetector may be configured to detect backscattered radiation emanating from the sample at a distance d, said backscattering distance, generally non-zero and less than a few millimeters, typically less than 15 mm or 10 mm.
    In this example, the light source 10 comprises two sources of elementary lights 10i and IO2. The first elementary light source 10i is an electroluminescent diode emitting in a first spectral band Δλι centered on a first wavelength λι equal to 660 nm. It is a light-emitting diode supplied by the manufacturer Kingbright under the reference APT1608SURCK. The second source of elementary light 102 is a light-emitting diode emitting in a second spectral band Δλ2 centered on a second wavelength λ2 equal to 940 nm. It is a light-emitting diode supplied by the manufacturer Kingbright under the reference APT1608F3C. Thus, the first spectral band Δλι preferably extends between 600 and 700 nm, which covers the visible red spectral band, while the second spectral band Δλ2 preferably extends between 700 and 1000 nm, and even more preferably between 810 nm - 1000 nm, which corresponds to a spectral band in the near infra-red. Preferably, the first spectral band Δλι and the second spectral band AÀ2 are different and do not overlap. By not overlapping, it is meant that most of the emission spectrum, and preferably 80% or even more than 90% of the intensity emitted, is not in the same spectral range.
    A microcontroller 15 controls the sequential activation of the sources of elementary lights 10i and IO2. Thus, the sample is successively illuminated by a first incident light beam 12i, in the first spectral band Δλι, and by a second incident light beam 122, in the second spectral band Δλ2.
    A photodetector 30 detects a first backscattered radiation 14i, in the first spectral band Δλι, under the effect of the illumination by the first incident light beam 12i, as well as a second backscattered radiation 142, in the second spectral band Δλ2 under the Effect of illumination by the first incident light beam 122. In the example shown, the photodetector is a photodiode provided by VISHAY under the reference BPW345, whose detection spectral band allows the detection of the first and second backscattered radiation. In this example, the backscattering distance d is 7 mm.
    A processor 32 is capable of establishing a detection function, corresponding to a temporal change in the intensity of a radiation detected by the photodetector, in each of the spectral bands. It can be connected to a memory 33, able to store instructions for implementing a method described in this description. It can also be connected to a display unit 34.
    According to another embodiment, shown in FIG. 1B, the device 1 is arranged in a so-called transmission configuration. In such a configuration, the sample extends between the light source 10 and the photodetector 30. The latter is then able to detect a radiation 14 transmitted by the sample along the axis of propagation Z. However, such a device is less compact than the backscatter device exposed in connection with FIG IA. In addition, a backscatter device, as shown in FIG. 1A, is more versatile than a device operating in transmission. Indeed, its operation is independent of the thickness of the body area analyzed. It can therefore be placed against different body areas, for example a wrist, a finger, or a leg.
    FIG. 2A represents a function S (t), called the detection function, representing the intensity. S, as a function of time, of a backscattered radiation (or transmitted) detected by the photodetector 30, in the first spectral band. Under the effect of cardiac activity, the intensity of the backscattered radiation follows a periodic temporal evolution, whose period is related to the heart rate hr. FIG. 2B represents the evolution, as a function of time, of a function, called derivative, representing a time derivative of the detection function. It is understood that it is easy to estimate the frequency of the function S '(t), the latter also corresponding to the frequency of the function S (t), which also corresponds to the desired heart rate hr. One known method of the prior art consists in using a low threshold Th | 0W and a high threshold Thhigh, so as to respectively detect a falling edge F | OW and a rising edge Fhigh in the derived function S '(t). The moments corresponding to a falling edge, or a rising edge, are called characteristic moments. They are respectively obtained by determining the times at which the derived function S '(t) crosses the low threshold and the high threshold, with a sampling period close. The frequency / derived function is obtained by calculating a period between two successive characteristic instants, or by an average of the time interval between several consecutive characteristic instants.
    Such an estimate is generally made in a single spectral band, whether it is a red spectral band or an infra-red spectral band. However, this type of estimation lacks robustness. In particular, movements of the illuminated body area, exposures to stray light sources, or simple electronic noises can distort the estimation of heart rate. Figure 3A shows a detail of a detection function and a derived function in a time interval of 1500 ms. This figure illustrates an example of detection of a falling edge, said untimely Ffaise, and a falling edge Ftrue, said real. The inventors have estimated that it is necessary to reduce the detection of untimely fronts, because their presence distorts the estimation of the heart rate.
    FIG. 3B represents estimates of the heart rate hrlt hr2 respectively calculated from a first detection function Si (t) obtained from an illumination of a sample in the first spectral band Δλι, and from a second detection function S2 (t) obtained from an illumination of the sample in the second spectral band Δλ2. On each of these estimates, there are untimely variations in the estimates, due to detections of untimely fronts such as the front described in connection with Figure 3A.
    The inventors have defined a method for avoiding the detection of untimely characteristic instants. This method, combining the detection of backscattered or transmitted signals in two spectral bands, is defined below, in connection with FIG. 4A, the main stages of which are presented below.
    Step 100: Arrangement of the device 1, so that the light source 10 is able to illuminate a sample, that is to say a body zone 20 of a living being, and that the photodetector is able to detect a radiation backscattered or transmitted by said body area following this illumination.
    Step 110: illumination of the sample 20 in the first spectral band Δλι (substep 110i) and in the second spectral band Δλ2 (substep 1102). Depending on the photodetector used, this illumination can be simultaneous or successive. In this example, a single, spectrally unresolved photodetector is used. The sample is illuminated successively by each elementary source 10i and 102, the duration of each illumination being 1.66 ms. The successive activation of each elementary light source, designated by the term "illumination sequence" is controlled by the microcontroller 15. Alternatively, the light sources can be activated continuously, the backscattered radiation (or transmitted) being detected by two different photodetectors, each being able to respectively detect said radiation in said first spectral band or said second spectral band. According to another variant, the photodetector may be spectrally resolved, which also allows illumination of the body zone 20 simultaneously according to the two spectral bands. Preferably, but optionally, after activation of the second light source, no light source is activated for 1.66 ms (sub-step 1103). The signal Sb detected by the photodetector 30 is then representative of a dark current of the latter.
    Step 120: Detection of backscattered (or transmitted) radiation by the sample following illumination in each spectral band. The photodetector generates a first detection signal Si depending on the intensity of the backscattered (or transmitted) radiation. The effect of the illumination of the sample in the first spectral band Δλι (sub-step 120i) and a second signal of detection S2 depending on the intensity of the backscattered radiation (or transmitted) 142 under the effect of the illumination of the sample in the second spectral band Δλ2 (substep I2O2). In this example, the first signal S1 and the second detection signal S2 are respectively detected during illumination by the first elementary source and the second elementary source. When no light source is activated, the photodetector acquires a background signal, or dark current Sb (substep I2O3). This dark current can be subtracted from the detection signals Si and S2.
    Thus, as shown in FIG. 4B, an illumination sequence At lasts 5ms, and is subdivided into three time periods of 1.66 ms, respectively corresponding to: the activation of the first elementary light source 10i, and the detection by the photodetector, a first signal Si representing the intensity of a first radiation 14i backscattered (or transmitted) by the sample; activating the second source of elementary light 102, and detecting, by the photodetector, a second signal S2 representing the intensity of a second radiation ΙΛ2 backscattered (or transmitted) by the sample; the detection by the photodetector of a background noise signal when no light source is activated.
    Step 130: establishing a first detection function Si (t) and a second detection function S2 (t) respectively representing the time evolution of the first detection signal S1 and the second detection signal S2. Each of these functions is obtained respectively by a temporal sampling of the first signal S1 and the second signal S2, the sampling frequency being, for example, 200 Hz, which corresponds to an acquisition of a first signal Si and a second signal S2 every 5 ms. The establishment of the each detection function may comprise a pretreatment step, smoothing type, to overcome a high frequency component of the detected signal. This pretreatment can take the form of the application of a low-pass filter or a sliding average. In this example, a sliding average is carried out at a time interval of 25 ms, ie 5 samples.
    Step 140: determining a first derived function S'i (t) and a second derived function S'2 (t). Each derived function is obtained by a difference of a detection function at two different times t and t + ôt. The time difference is preferably less than 500 ms, or even 100 ms. In this example, t and t + are successive instants, i.e., spaced apart from the sampling period, ie 5 ms. The derived function can be obtained by normalizing the difference previously described by the time difference, which corresponds to the conventional definition of a rate of change.
    In other words,
    (Γ).
    The second derived function S'2 (t) is obtained identically to the first derived function S'i (t), from the second detection function S2 (t).
    Step 150: Identification of characteristic moments. By characteristic moment, one understands a time at which the function of detection or its derived function reaches a particular value, crosses a threshold or reaches a local extremum, for example local minimum or maximum local. In this example, as described with reference to FIGS. 2B and 3A, a characteristic instant corresponds to the moment when a derived function crosses a threshold Th. Step 150 then comprises a comparison of each value of each derived function with a threshold Th, so as to detect a falling edge or a rising edge. When the value of a derived function, for example the first derivative function S'i (t), crosses such a threshold, a time window W is opened. The duration of this time window is short, for example between 5 and 100 times the sampling period. It is preferably less than 500 ms and typically between 20 ms and 200 ms. If, in this time window W, the other derived function, in this case S'2 (t) also crosses said threshold, the crossing of the threshold is validated for the two derived functions. The time corresponding to the crossing of the threshold, by one of the two derivative functions, is selected as being a characteristic instant t ,. The duration of the time window W may be predetermined or adjustable.
    FIGS. 5A and 5B illustrate step 150. FIG. 5A shows a first detection function Si (t) and its derived function S'i (t). FIG. 5B also shows a second detection function S2 (t) and its derived function S'2 (t). Figure 5B is similar to Figure 3A previously described. We observe a first crossing of a threshold Th, by the second derivative function S'2 (t), at t = ti. During this crossing, a time window W is open, of duration 100 ms. During this time window, no crossing of Th threshold is detected for the first derivative function S'i (t). The characteristic moment ti is thus invalidated. There is also a second crossing of the threshold Th by the first derivative function S'i (t) at t = t2. During this crossing, a new time window W is opened, during which the second crossing of the threshold is detected for the second derived function S'2 (t). It is then considered that at time t2, the two threshold crossings are made in time coincidence, that is to say simultaneously, to a few sampling periods. The time t2 is therefore selected as being a characteristic moment t, to be considered for evaluating the heart rate.
    Step 160: Determining the heart rate hr. From the characteristic instants t, selected during step 150, a frequency / occurrence of the successive characteristic instants is established, this frequency corresponding to the heart rate hr. For example, the frequency of occurrence is obtained by averaging the frequency of occurrence of a number N of successive characteristic instants t ,. The frequency / j attributed to a characteristic instant tj can then be established according to the average time difference between N successive successive instants at said characteristic instant, so that:
    (2)
    The heart rate / ir * at time tj is equal to ft. A change of unit can then be operated, to obtain a heart rate in min -1.
    Figures 6A and 6B illustrate the advantage conferred by the invention. In these figures, there is shown an evaluation of the heart rate of a man by placing a backscatter device, as shown in Figure IA, at the thumb. FIG. 6A shows an estimate of the heart rate according to the prior art, considering independently measurements in the first spectral band and measurements in the second spectral band. FIG. 6B shows an estimate of the heart rate from characteristic instants appearing in time coincidence, that is to say simultaneously, with the width of the time window close, in each spectral band. The detection functions used to establish FIGS. 6A and 6B are analogous. The heart rate determined by implementing the invention is more stable. In particular, the parasitic fluctuations appearing in FIG. 6A at t = 80 ms, t = 130 s and t = 180 s, do not appear in FIG. 6B.
    Figures 6C and 6D are respectively similar to Figures 6A and 6B, the device being disposed at the wrist of a man. There is also an improvement in the accuracy of the estimate when the invention is applied. The invention may be implemented on devices in transmission or backscatter carried by a person. The backscattering configuration is particularly suitable for integration into a compact watch-type device, a nomadic actimetry tracking device or a dermal patch. In order to improve the reliability of the estimate, the device will preferably be held in contact with the skin of a person, or at a fixed distance from the latter, by means of a bracelet or other rigid or elastic frame. The invention may be applied to the monitoring of living beings, newborn, elderly, sports or risky. The use of the red and infra-red spectral bands are well suited for integration into pulsed oximetry devices, based on these same spectral bands, so as to determine other physiological parameters, such as blood saturation, according to methods known.
    权利要求:
    Claims (11)
    [1" id="c-fr-0001]
    A method for estimating a heart rate of a living being comprising the steps of: a) illuminating a body area (20) of said living being with an incident light beam (12, 12i, 122) according to a first spectral band (Δλι); b) detecting a transmitted or backscattered light radiation (14, 14ι, 142) in said first spectral band (Δλι) by said body area under the effect of said illumination; c) determining a first detection function (Si (t)) representing a temporal evolution of an intensity of the light radiation thus detected (Si); d) identifying characteristic instants (t,) from said first detection function (Si (t)), and calculating a frequency of occurrence (/) of said characteristic moments; e) estimating a heart rate (hr) from said occurrence frequency (/); the method being characterized in that: steps a) to b) are also implemented in a second spectral band (Δλ2), so that step c) comprises a determination of a second detection function (S2 (t)) representing a temporal evolution of an intensity of the light radiation detected in the second spectral band (Δλ2); step d) comprises an identification of characteristic instants from the second detection function and a selection of characteristic instants (t,), identified from each detection function, and appearing in time coincidence, the frequency of occurrence (/) being calculated from the characteristic moments thus selected.
    [2" id="c-fr-0002]
    2. The method of claim 1, wherein the second spectral band (Δλ2) is different from the first spectral band (Δλι).
    [3" id="c-fr-0003]
    3. Method according to any one of the preceding claims, wherein step d) comprises a calculation of a first derived function (S'i (t)) from the first detection function (Si (t)). , and a second derived function (S'2 (t)) from the second detection function (S2 (t)), as well as the identification of characteristic times from each of said derived functions (S '). i (t), (S'2 (t))).
    [4" id="c-fr-0004]
    4. The method of claim 3, wherein each derived function is obtained by a difference between the value of a detection function at two different times (t, t + ôt).
    [5" id="c-fr-0005]
    5. Method according to any one of the preceding claims, wherein: the first spectral band (Δλι) has wavelengths between 600 and 700 nm; - The second spectral band (Δλ2) has wavelengths between 750nm and 1 μιτι.
    [6" id="c-fr-0006]
    6. Estimation method according to any one of the preceding claims, wherein the first spectral band (Δλι) extends between 600 nm and 700 nm, while the second spectral band (Δλ2) extends between 750 nm and 1 pm
    [7" id="c-fr-0007]
    7. A method according to any one of the preceding claims, wherein the detected radiation is radiation backscattered by said body area (20) under the effect of its illumination.
    [8" id="c-fr-0008]
    8. Device for estimating a heart rate of a living being, comprising: a light source (10) capable of emitting an incident light beam (12i, 122) propagating towards a body area (20) of said being living, in a first spectral band (Δλι) and in a second spectral band (Δλ2); a photodetector (30), able to detect, in the first spectral band (Δλι) and in the second spectral band (Δλ2) a radiation (14i, 142) backscattered or transmitted by said body area (20), under the effect of its illumination by said incident light beam; a processor (32) configured to implement steps c) to e) of the method of any one of claims 1 to 7.
    [9" id="c-fr-0009]
    9. Device according to claim 8, wherein the photodetector (30) is adapted to detect radiation (14i, 142) backscattered by said body zone (20) under the effect of its illumination.
    [10" id="c-fr-0010]
    10. Device according to any one of claims 8 or 9, wherein the first spectral band (Δλι) is different from the second spectral band (Δλ2).
    [11" id="c-fr-0011]
    11. Device according to any one of claims 8 to 10, wherein the light source (10) comprises: a first elementary light source (10i) adapted to emit a first incident light beam (12i) according to the first band spectral (Δλι); a second source of elementary light capable of emitting a second incident light beam (122) according to the second spectral band (Δλ2).
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    同族专利:
    公开号 | 公开日
    EP3210531B1|2022-02-16|
    US9778111B2|2017-10-03|
    US20170248469A1|2017-08-31|
    FR3048173B1|2018-03-16|
    EP3210531A1|2017-08-30|
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    法律状态:
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    2017-09-01| PLSC| Publication of the preliminary search report|Effective date: 20170901 |
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    申请号 | 申请日 | 专利标题
    FR1651656|2016-02-29|
    FR1651656A|FR3048173B1|2016-02-29|2016-02-29|METHOD FOR ESTIMATING CARDIAC FREQUENCY AND DEVICE THEREOF|FR1651656A| FR3048173B1|2016-02-29|2016-02-29|METHOD FOR ESTIMATING CARDIAC FREQUENCY AND DEVICE THEREOF|
    EP17158181.2A| EP3210531B1|2016-02-29|2017-02-27|Method for estimating a cardiac frequency, and associated device|
    US15/445,021| US9778111B2|2016-02-29|2017-02-28|Method for estimating a cardiac frequency and associated device|
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